The sixth volume in a series of handbooks on graphene research and applications The Handbook of Graphene, Volume 6: Biosensors and Advanced Sensors discusses the unique benefits that the discovery of graphene has brought to the sensing and biosensing sectors. It examines graphene's use in leading-edge technology applications and the development of a variety of graphene-based sensors. The handbook looks at how graphene can be used as an electrode, substrate, or transducer in sensor design. Graphene-based sensor detection has achieved up to femto-levels, with performances delivering the advantages of greater selectivity, sensitivity, and stability.