This textbook is an important novel menu for multiple variables regression entitled "regularized regression". It is a must have for identifying unidentified leading factors. Also, you get fitted parameters for your overfitted data. Finally, there is no more need for commonly misunderstood p-values. Instead, the regression coefficient, R-value, as reported from a regression line has been applied as the key predictive estimator of the regression study. With simple one by one variable regression it is no wider than -1 to +1. With multiple variables regression it can easily get > +1 or < -1.="" this="" means="" we="" have="" a="" seriously="" flawed="" regression="" model,="" mostly="" due="" to="" collinearity="" or="" non-linear="" data.="" completing="" the="" analysis="" will="" lead="" to="" overfitting,="" and="" thus="" a="" meaningless="" significant="" study="" due="" to="" data="" spread="" wider="" than="" compatible="" with="" random.="" in="" order="" for="" the="" regression="" coefficients="" to="" remain="" in="" the="" right="" size,="" fortunately="" a="" shrinking="" procedure="" has="" been="" invented.="" in="" the="" past="" two="" decades="" regularized="" regression="" has="" become="" a="" major="" topic="" of="" research,="" particularly="" with="" high="" dimensional="" data.="" yet,="" the="" method="" is="" pretty="" new="" and="" infrequently="" used="" in="" real-data="" analysis.="" its="" performance="" as="" compared="" to="" traditional="" null="" hypothesis="" testing="" has="" to="" be="" confirmed="" by="" prospective="" comparisons.="" most="" studies="" published="" to="" date="" are="" of="" a="" theoretical="" nature="" involving="" statistical="" modeling="" and="" simulation="" studies.="" the="" journals="" nature="" and="" science="" published="" 19="" and="" 10="" papers="" of="" this="" sort="" in="" the="" past="" 8="" years.="" the="" current="" edition="" will="" for="" the="" first="" time="" systematically="" test="" regularized="" regression="" against="" traditional="" regression="" analysis="" in="" 20="" clinical="" data="" examples.="" the="" edition="" is="" also="" a="" textbook="" and="" tutorial="" for="" medical="" and="" healthcare="" students="" as="" well="" as="" recollection="" bench="" and="" help="" desk="" for="" professionals.="" each="" chapter="" can="" be="" studied="" as="" a="" standalone,="" and,="" using,="" real="" as="" well="" as="" hypothesized="" data,="" it="" tests="" the="" performance="" of="" the="" novel="" methodology="" against="" traditional="" regressions.="" step="" by="" step="" analyses="" of="" 20="" data="" files="" are="" included="" for="" self-assessment.="" the="" authors="" are="" well="" qualified="" in="" their="" field.="" professor="" zwinderman="" is="" past-president="" of="" the="" international="" society="" of="" biostatistics="" and="" professor="" cleophas="" is="" past-president="" of="" the="" american="" college="" of="" angiology.="" the="" authors="" have="" been="" working="" together="" for="" 25="" years="" and="" their="" research="" can="" be="" characterized="" as="" a="" continued="" effort="" to="" demonstrate="" that="" clinical="" data="" analysis="" is="" a="" discipline="" at="" the="" interface="" of="" biology="" and="" mathematics.="" -1.="" this="" means="" we="" have="" a="" seriously="" flawed="" regression="" model,="" mostly="" due="" to="" collinearity="" or="" non-linear="" data.="" completing="" the="" analysis="" will="" lead="" to="" overfitting,="" and="" thus="" a="" meaningless="" significant="" study="" due="" to="" data="" spread="" wider="" than="" compatible="" with="" random.="" in="" order="" for="" the="" regression="" coefficients="" to="" remain="" in="" the="" right="" size,="" fortunately="" a="" shrinking="" procedure="" has="" been="" invented.="" in="" the="" past="" two="" decades="" regularized="" regression="" has="" become="" a="" major="" topic="" of="" research,="" particularly="" with="" high="" dimensional="" data.="" yet,="" the="" method="" is="" pretty="" new="" and="" infrequently="" used="" in="" real-data="" analysis.="" its="" performance="" as="" compared="" to="" traditional="" null="" hypothesis="" testing="" has="" to="" be="" confirmed="" by="" prospective="" comparisons.="" most="" studies="" published="" to="" date="" are="" of="" a="" theoretical="" nature="" involving="" statistical="" modeling="" and="" simulation="" studies.="" the="" journals="" nature="" and="" science="" published="" 19="" and="" 10="" papers="" of="" this="" sort="" in="" the="" past="" 8="" years.="" the="" current="" edition="" will="" for="" the="" first="" time="" systematically="" test="" regularized="" regression="" against="" traditional="" regression="" analysis="" in="" 20="" clinical="" data="" examples.="" the="" edition="" is="" also="" a="" textbook="" and="" tutorial="" for="" medical="" and="" healthcare="" students="" as="" well="" as="" recollection="" bench="" and="" help="" desk="" for="" professionals.="" each="" chapter="" can="" be="" studied="" as="" a="" standalone,="" and,="" using,="" real="" as="" well="" as="" hypothesized="" data,="" it="" tests="" the="" performance="" of="" the="" novel="" methodology="" against="" traditional="" regressions.="" step="" by="" step="" analyses="" of="" 20="" data="" files="" are="" included="" for="" self-assessment.="" the="" authors="" are="" well="" qualified="" in="" their="" field.="" professor="" zwinderman="" is="" past-president="" of="" the="" international="" society="" of="" biostatistics="" and="" professor="" cleophas="" is="" past-president="" of="" the="" american="" college="" of="" angiology.="" the="" authors="" have="" been="" working="" together="" for="" 25="" years="" and="" their="" research="" can="" be="" characterized="" as="" a="" continued="" effort="" to="" demonstrate="" that="" clinical="" data="" analysis="" is="" a="" discipline="" at="" the="" interface="" of="" biology="" and="" mathematics.="">