The prevalence of overweight and obesity has increased exponentially during the past 30 years worldwide, and now it is considered a global pandemic. Obesity is a multifactorial condition caused by a complex interaction between biological, social, and psychological factors. Most of the obesity treatments were ineffective, particularly those based on restrictive diets, which do not affect a long-term weight loss and can contribute to higher psychological distress. However, interventions based on mindful eating and non-judgmental awareness of physical and emotional sensations related to the experience of eating seem to be effective in reducing dysfunctional eating behaviors and promoting physical and psychological well-being.